Mise en place d\u27un programme de formation documentaire en théologie et science des religions

Intervention aux 5èmes Rencontres FORMIST (Lyon, 9 juin 2005). Compte-rendu d\u27expériences d\u27un bibliothécaire à la bibliothèque de la faculté de théologie de Lausanne. Analyse des besoins documentaires et informationnels en science des religions et association des bibliothécaires aux enseignements méthodologiques

An active connection mechanism for modular self-reconfigurable robotic systems based on physical latching

This article presents a robust and heavy duty physical latching connection mechanism, which can be actuated with DC motors to actively connect and disconnect modular robot units. The special requirements include a lightweight and simple construction providing an active, strong, hermaphrodite, completely retractable connection mechanism with a 90 degree symmetry1 and a no-energy consumption in the locked state. The mechanism volume is kept small to fit multiple copies into a single modular robot unit and to be used on as many faces of the robot unit as possible. This way several different lattice like modular robot structures are possible. The large selection for dock-able connection positions will likely simplify self-reconfiguration strategies. Tests with the implemented mechanism demonstrate its applicative potential for self-reconfiguring modular robot

5es Rencontres FORMIST - 2005

Actes des 5èmes Rencontres FORMIST qui se sont déroulées à Lyon le 9 juin 2005. Compétences informationnelles pour une meilleure insertion universitaire ; Le développement des compétences informationnelles à l\u27université de Laval ; Comparaison des conceptions pédagogiques de la maîtrise de l\u27information chez des universitaires britanniques de différentes disciplines ; Quelle recherche d\u27information pour une discipline donnée ? ; La relation de la discipline à la documentation en philosophie ; Mise en place d\u27un programme de formation documentaire en théologie et science des religions ; La relation entre discipline et documentation et ses répercussions dans les formations à l\u27information en sciences de la vie ; A l\u27ouest, du nouveau ? Regards sur quelques pratiques américaines

Camille Focant - André Wénin (dir.), Analyse narrative et Bible. Deuxième colloque international du RRENAB

Bourquin Yvan. Camille Focant - André Wénin (dir.), Analyse narrative et Bible. Deuxième colloque international du RRENAB. In: Revue théologique de Louvain, 38ᵉ année, fasc. 1, 2007. pp. 80-85

Camille Focant - André Wénin (dir.), Analyse narrative et Bible. Deuxième colloque international du RRENAB

Bourquin Yvan. Camille Focant - André Wénin (dir.), Analyse narrative et Bible. Deuxième colloque international du RRENAB. In: Revue théologique de Louvain, 38ᵉ année, fasc. 1, 2007. pp. 80-85

Pharmacological disruption of the Notch transcription factor complex

Notch pathway signaling is implicated in several human cancers. Aberrant activation and mutations of Notch signaling components are linked to tumor initiation, maintenance, and resistance to cancer therapy. Several strategies, such as monoclonal antibodies against Notch ligands and receptors, as well as small-molecule γ-secretase inhibitors (GSIs), have been developed to interfere with Notch receptor activation at proximal points in the pathway. However, the use of drug-like small molecules to target the downstream mediators of Notch signaling, the Notch transcription activation complex, remains largely unexplored. Here, we report the discovery of an orally active small-molecule inhibitor (termed CB-103) of the Notch transcription activation complex. We show that CB-103 inhibits Notch signaling in primary human T cell acute lymphoblastic leukemia and other Notch-dependent human tumor cell lines, and concomitantly induces cell cycle arrest and apoptosis, thereby impairing proliferation, including in GSI-resistant human tumor cell lines with chromosomal translocations and rearrangements in Notch genes. CB-103 produces Notch loss-of-function phenotypes in flies and mice and inhibits the growth of human breast cancer and leukemia xenografts, notably without causing the dose-limiting intestinal toxicity associated with other Notch inhibitors. Thus, we describe a pharmacological strategy that interferes with Notch signaling by disrupting the Notch transcription complex and shows therapeutic potential for treating Notch-driven cancers